NSI-189 is an experimental, novel potential antidepressant that is under
investigation byNeuralstem, Inc. for the treatment for major depressive
disorder (MDD), as well as for cognitive impairment and
neurodegeneration. Research into NSI-189 has been funded by theDefense
Advanced Research Projects Agency (DARPA) and the National Institutes of
Health(NIH).The mechanism of action of NSI-189 appears to be activation
of neurogenesis in thehippocampus and possible enlargement of this
structure,[2] but how the drug mediates these effects is unknown and
binding studies have so far failed to identify any certain molecular
targets for the drug. As stated by Neuralstem, NSI-189 is a "new
chemical entity with [a] novel mechanism of action, molecular target yet
unknown, but not mediated by SSRI or SNRIor by BDNF release or via any
known GPCRs, kinases, or channels." The drug was discovered via
high-throughput screening of a library of 10,269 compounds for
neurogenic effects in vitro.
NSi-189 powder
Dosage:
Subjects in human trials have been given up to 100 mg a day and did not appear to develop any negative side effects.
Application:
NSI-189 has been proved that is thought to potentially promote
increased neuronal production whilst treat depression is NSI-189. This
article discusses NSI-189 and how this novel nootropic agent can
revolutionize the treatment for depression, and possibly other
neurodegenerative disorders.
NSI-189 increases the volume within the hippocampus. In so doing,
hippocampal volume and healthy brain cell density is increased thereby
improving mod and cognitive performance. Aside from increasing
hippocampal volume, the drug also improves neuronal cell functionality.
It works it promoting healthy neuronal cell growth whilst repair damaged
areas in the brain.
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