Dietary Supplement Nootropics Supplement Powder
PRL-8-53 powder
Basic Info.
Name:PRL-8-53
Chemical name:Methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate
Synonyms:PRL-8053;PRL-8-53;Methyl
3-(2-(benzyl(Methyl)aMino)ethyl)benzoate
hydrochloride;3-(2-Benzyl(methyl)aminoethyl)benzoic acid methyl ester
hydrochloride;m-[2-(Benzylmethylamino)ethyl]benzoic acid methyl ester
hydrochloride;Benzoic acid, 3-(2-(Methyl(phenylMethyl)aMino)ethyl)-,
Methyl ester, hydrochloride
CAS 51352-87-5
MF:C18H22ClNO2
MW 319.82578
Shelf life:2 years
Purity:99%
Package:50g/foil bag or as your inquiry
Dosage:
Subjects in human trials have been given up to 100 mg a day and did not appear to develop any negative side effects.
Reference FOB Price:$1/g
MOQ:10g
Specification:ISO9001,USP,BP,GMP
Trade Mark:CQSP
Port:Shenzhen/Shanghai,China
Production Capacity:5000kg/month
Skype/E-mail : summer at chembj.com
Abstract
The effect of 3-(2-benzylmethylaminoethyl) benzoic acid methyl ester
hydrochloride (PRL-8-53) on learning and on retention of verbal
information in human subjects was investigated. Using the serial
anticipation method under double-blind conditions it was found that
PRL-8-53 causes slight improvement of acquisition. Retinetion of verbal
information was found improved to a statistically significant degree
(most P values better than 0.01, some better than 0.001). No significant
changes were found for either visual reaction time or motor control
after drug when compared with placebo values.
Description
PRL-8-53 (chemical name Methyl 3-(2-(benzyl(methyl)amino)ethyl)benzoate)
is a synthetic nootropic compound discovered in 1972 and patented in
1975 by the late Dr. Nikolaus Hansl, a neuropharmacologist at Creighton
University in Omaha, Nebraska. Preliminary animal tests indicated that
the compound was both safe and significantly nootropic, boosting
avoidance learning in rodents with no adverse effects. But the real
interest in PRL-8-53 was sparked by a 1978 study on human volunteers,
which showed that a single dose of the compound could improve word
retention scores by more than 200%.
HOW IT WORKS?
PRL-8-53's exact mechanisms of action are not well understood, but it is
generally believed to regulate the brain's production of and response
to several crucial neurotransmitters. In his reports on human and animal
studies Hansl indicated that PRL-8-53 potentiates dopamine, partially
restricts production of serotonin, and enhances the brain's response to
acetylcholine.
Though Hansl's research report on the 1978 human study suggests those
actions, it does not clearly delineate the mechanism of action.The fact
that older subjects saw the most nootropic benefit from taking the drug
supports the concept that dopamine modulation plays a major role in
PLR-8-53's effects. Up-regulating the normal age-related lessening of
dopamine production that is associated with cognitive decline could have
a significant positive impact on both learning and memory.
Dosage
The only human study on PRL-8-53 was based on the ingestion of a single 5
mg dose. There is no data on the effectiveness or potential toxicity of
any other dosage in humans.
SIDE EFFECTS
No adverse effects from a single 5 mg dose of PRL-8-53 were observed in
the human study. Animal studies suggest that the compound has a high
therapeutic threshold, but evidence is very limited because no
comprehensive toxicity studies have been completed.
The Wall