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Palmitoylethanolamide(PEA) also called N-2 hydroxyethyl palmitamide or palmitoylethanolamine is a chemical that belong to a group of fatty acid amides. It is a biologically active, naturally occuring lipid that acts on CR2 (cannabinoid receptor) and interacts with inflammatory cells in our nervous system. Palmitoylethanolamide supplement has been proved to have powerful anti-inflammatory and analgesic activity. It also influences many physiological functions that are related to cellular and metabolic homeostasis.To get more news about Palmitoylethanolamide(PEA) , wisepowder official website is the best place for you.
2. What is Palmitoylethanolamide(PEA) Made From?
Palmitoylethanolamide (PEA) (544-31-0) is naturally produced in the body when the body needs to combat pain or inflammation. Several plants and animals also produce PEA. This chemical can therefore be extracted from peanuts, alfalfa, soy lecithin, milk, soybeans, and egg yolk.

3. How Does Palmitoylethanolamide(PEA) Work?
Palmitoylethanolamide (PEA) stimulates PPAR alpha which is an anti-inflammatory, energy-enhancing, and fat-burning receptor. Through stimulation of this receptor, Palmitoylethanolamide inhibits the release of several inflammatory substances and action of pro-inflammatory genes therefore reducing inflammation. This also triggers regulation of lipid metabolism.

PEA triggers a number of indirect receptor-mediated activities. PEA indirectly stimulates cannabinoid receptors via different indirect mechanisms. Palmitoylethanolamide indirectly activate cannabinoid receptors such as CB1 and CB2 by functioning as a false substrate for FAAH (fatty acid amide hydrolase), the enzyme used in the endocannabinoid AEA degradation, therefore leading to a lowered degradation of AEA.

This action causes increased AEA levels and, in turn, more stimulation of cannabinoid receptor-mediated signaling. Also, recent research has shown that Palmitoylethanolamide boosts CB2 receptor mRNA levels and protein following PPAR-α activation.

PEA therefore lowers the activity of FAAH which breaks down cannabinoid anandamide. This boosts calming anandamide levels in your body, helping you to feel relaxed and fight pain.