Lorcaserin is an orally administered medication that promotes weight
loss. It is used with diet and exercise in overweight adults with a
weight-related medical problem or obese adults to lose weight and keep
it off.
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Lorcaserin is a serotonin 2C (5-HT2C) receptor agonist. Although the
exact mechanism of action is not known, lorcaserin is thought to
selectively stimulate 5-HT2C receptors in the hypothalamus, the area of
the brain known to play a major role in regulating hunger and food
intake. By activating these receptors, lorcaserin may decrease food
consumption by decreasing appetite and making a person feel full even
after eating less food than usual.
Lorcaserin was approved by the FDA in June, 2012. Use and distribution
of lorcaserin is under strict control by the federal government as it
has a potential for abuse and drug dependence. As such, lorcaserin is
classified as a schedule IV controlled substance.
The recommended dose of lorcaserin is 10 mg administered by mouth twice a
day. Lorcaserin may be taken without regard to meals. Lorcaserin should
be discontinued in patients who fail to achieve at least a 5% weight
loss by week 12 since these patients are not likely to experience
meaningful weight loss with continued treatment.
Due to the potential risk for serotonin syndrome, a rare but serious
disorder caused by abnormally high levels of serotonin, extreme caution
should be exercised when using lorcaserin with certain medications.
Examples include triptans (a type of medication used for treating
migraine headaches), linezolid (Zyvox), tryptophan, lithium (Lithobid,
Eskalith), tramadol (Ultram), St. John's Wort, dextromethorphan (a
common over-the-counter medicine for treating colds and coughs), and
various classes of commonly used antidepressants including selective
serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake
inhibitors (SNRIs), tricyclic antidepressants (TCAs), and monoamine
oxidase inhibitors (MOAIs).
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